My present research interest lies in understanding the role of specific nutrients like vitamin in immune system. We would determine how the nutrients affect the adaptive immune system by regulating the development of T helper cells. T helper cells play important role in protecting us from various pathogens by producing cytokines. However, if unregulated the immune responses generated by T helper cells can cause various inflammatory disorders. Based on the cytokines in the microenvironment and produced and the expression of transcription factors, T helper cells have been classified into distinct subsets. Among different vitamins, role of vitamin A and vitamin D have been explored in the differentiation of certain T helper cells. In addition, the function of these vitamins have also been explored in disease models like allergic asthma and experimental autoimmune encephalomyelitis. We would like to define how vitamin A and D regulate the development of various T helper cells including IL-9-rpdocing Th9 cells. IL-9, a pleiotropic cytokine has been demonstrated to act on multiple cell types. T cells and mast cells are the key producers of IL-9. Th9 cells play important role in the development of asthma, exacerbate ulcerative colitis; while they aid in the expulsion of helminthic infection and antitumor activity in mouse model of melanoma. Thus, delineating the role of vitamin A and vitamin D in regulating the differentiation of Th9 cells will aid us developing future therapeutics. We would like to build a network of inflammatory diseases whereby IL-9 play key role.
Furthermore, we aim to identify diagnostic, predictive and prognostic markers of the inflammatory disorder that can used to develop on-site detection diagnostic system to identify multiple biomarkers of rheumatoid arthritis.
Size-dependent cellular uptake and TLR4 attenuation by gold nanoparticles in lung adenocarcinoma cells by Vyas S. P., Goswami R. Nanomedicine 14 229-253 (2019)
A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease by Vyas S. P., Goswami R. Frontiers in Immunology 9 - (2018)
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells by Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F Journal of Immunology Apr 15;194(8) 3567-3582 (2015)
Skin exposure promotes a Th2-dependent sensitization to peanut allergens. by Tordesillas L, Goswami R, Benedé S, Grishina G, Dunkin D, Järvinen KM, Maleki SJ, Sampson HA, Berin MC Journal of Clinical Investigation Nov 124(11) 4965-4975 (2014)
Th9 cell development requires a BATF-regulated transcriptional network by Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, Walsh D, Olson MR, Kim MH, Tepper RS, Sun J, Kim CH, Taparowsky EJ, Zhou B, Kaplan MH Journal of Clinical Investigation Nov 123(11) 4641-4653 (2013)
Yoking OX40 to regulation of IL-9 by Goswami R, Kaplan MH Nature Immunology Oct 13(10) 942-943 (2012)
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. by Goswami R, Kaplan MH Journal of Immunology Sep 15: 189(6) 3026-3033 (2012)
The Transcription Factors Hox Required for Animal Development, Elucidates a Novel Mechanism of Regulating Th17 and Th9 Cell Differentiation Science and Engineering Research Board (SERB)
RA Detect One Platform-Multiple Biomarker Detection of Rheumatoid Arthritis Department of Science and Technology, Ministry of Science and Technology (International Multilateral and Regional Cooperation Division)
Vyas Shachi Pranjalkumar
Area of Research: Molecular Immunology
Arman Kunwar Hansda
Area of Research: Immunology
Area of Research: Immunology